This is a compound that is primarily used for pharmacological use. 18-Hydroxycorticosterone (CAS 561-65-9) has chemical makeup of C21H30O5, it is also known as 20-dione, 11beta, 21-trihydroxy-4-pregnene-3 among other synonyms. IIt is derived from corticosterone. It is primarily used in the synthesis of aldosterone with aldosterone synthase.
In the human body, hydroxycorticosterone is used by the aldosterone synthase enzyme found in zona glomerulosa. This enzyme is used in the process of creating aldosterone. This is a steroid hormone found in the adrenal cortex of the adrenal glands, used in the regulating blood pressure by increasing absorption rates of water and ions in the kidney, leading to the secretion of potassium, and consequent conservation of sodium, which ultimately regulates blood pressure in the body.
It is therefore naturally located in extracellular and membranes, blood, and the adrenal gland. Abnormal quantities in the blood lead to terminal aldosterone biosynthesis defects.
Medical use of Synthetic Hydroxycorticosterone
It is used in a differential diagnosis of hyperaldosteronism because of adrenal adenoma. This is tested in patients with preexisting hypertension, abnormal renal-potassium wastage, and hypokalemia. Both bilateral hyperplasia and adrenal adenoma are known to increase the levels of 18-Hydroxycorticosterone, but using serum levels of 18-OH B from predetermined levels, bilateral hyperplesia can be ruled out.
The detection of Hydroxycorticosterone levels is done through extraction, then subjected to chromatography and a radio-immunoassay. or mass spectrometry. To assist labs with the detection and accurate analysis of this hormone, IsoSciences synthesizes and supplies unlabeled and labeled forms of this molecule.
8066UNL Unlabeled Hydroxycorticosterone (CAS 561-65-9)
8066 D-labeled Hydroxycorticosterone (CAS 1257742-38-3; d4)
We are proud to offer a selection of stable labeled hormones. For your convenience, we sell unlabeled hormones alongside our list of labeled hormones. Our selection includes CertiMass™ Reference Standards, which are standard solutions for many of our premier compounds
If you are unable to find the desired hormone in our catalog, please contact us by email or phone (610-337-3762) we will be more than happy to provide a quote on custom synthetic work.