Custom Synthesis

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IsoSciences develops custom synthesized internal standards to satisfy the needs of world leaders in diagnostic testing laboratories, research universities, pharmaceuticals and government agencies including CDC, NIH and NIST. The diverse nature of our expertise in 2H, 13C and 15N labeling techniques in heterocyclic, steroid, sugar, vitamin, natural product, homo-/heterogeneous catalysis and for organosilicon chemistry has allowed IsoSciences to tackle virtually any synthetic project.

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Custom Synthesized Internal Standards That Focuses on Isotope Chemistry

IsoSciences’ main focus is isotope chemistry. We work with our customers to design a compound with strategically placed isotopes to meet their needs. If the application is LC-MS/MS, the isotopes are placed in non-exchangeable positions and in desired molecule fragments to ensure the internal standard allows for accurate measurements. By shifting to 13C and 15N isotopes the customer can be assured they will receive a superior standard that co-elutes exactly with their analyte.

A complete certificate of analysis is issued with every compound. This includes structural identity by 1H-NMR and 13C-NMR, purity assessment by HPLC-UV, GC-FID or HPLC-ELSD and isotope incorporation by LC-MS/MS or GC-MS. IsoSciences compounds routinely analyze over 98% pure and 98% isotope incorporation with no unlabeled material detected.

IsoSciences looks forward to working with customers on any synthetic process. Whether a synthetic scheme is provided or requires a novel route, IsoSciences can rapidly deliver a quotation with anticipated delivery times. Our customers are continuously updated throughout the process and the structure is treated with the upmost confidentiality.

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