The extensive experience in tritium labeling found at the IsoSciences radiolabeling facility allows us to undertake the many chemical conversions and protections necessary to complete a very broad variety of synthetic projects. We recognize that not all tritium labeling projects are simple catalytic tritium exchange chemistries and have developed equipment and resource capabilities that allow us to complete everything from the complete synthesis of precursors, to simple tritium exchange reactions to more complex tritium incorporation as dictated by molecule limitations or client needs.
IsoSciences’ radioisotope synthesis team has experience with multiple nuclei; 3H, 14C, 125I, 11C, 18F, 77Br, and 195Au HHH and the incorporation of these radioisotope in pharmaceutical related chemistries and broader, general molecules. All of IsoSciences radio labeling staff have 15-20 years, are internationally recognized for their work and have substantial experience working within major pharmaceutical organizations. The support received from the stable isotope research and development lab also adds support and significant synthetic depth and knowledge. The stable isotope team includes many advanced degree chemists with specialties in natural products, annulations, sugars, heterocyclics, APIs and toxin syntheses.
While it is not possible to list all the chemistries that can be undertaken in the tritium labeling facility, a representative list of important tritium incorporation chemistries includes:
- Using tritium gas
- With sodium borotritide/palladium acetate (in presence of another Pd/C reducible group)
- Double bond/triple bond reduction using tritium gas
- Reduction using sodium borotritide
- Methylation using CT3I
- Tritium/hydrogen exchange
- Tritium gas and Crabtree's catalyst/Rh black/other catalyst
- With tritiated water and a catalyst (such as Platinum, Tris(triphenylphosphine) ruthenium chloride, etc)
Custom Tritium Labels