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IsoSciences Introduces Extensive Line of Isotopically Labeled Vitamin K Products


IsoSciences Introduces Extensive Line of Isotopically Labeled Vitamin K Products

IsoSciences now offers a diverse selection of stable labeled Vitamin K analytes for the clinical diagnostics market.

King of Prussia, PA – February 19, 2016

IsoSciences, LLC, King of Prussia, PA., is pleased to announce the availability of a newly developed diverse selection of isotopically labeled Vitamin K analytes, including Vitamin K1-[13C6] (Phytonadione-[13C6], Catalog #14329), Vitamin MK-4-[13C6] (Menaquinone-4-[13C6], Catalog #15277), Vitamin MK-7-[13C6] (Menaquinone-7-[13C6], Catalog #15278) and Vitamin MK-9-[13C6] (Menaquinone-9-[13C6], Catalog #15279). This represents the first time that Vitamin K Carbon-13 stable labeled internal standards are available for clinical diagnostic analyses on mass spectroscopy based systems.

Vitamin K is a fat-soluble vitamin that is primarily known for the important role it plays in blood clotting; however, vitamin K is also absolutely essential to building strong bones, preventing heart disease, and plays a crucial part of other bodily processes. Despite these known benefits, vitamin K is sometimes referred to as "the forgotten vitamin" because its major benefits are often overlooked. Recent studies suggest Vitamin k is an important adjunct to vitamin D, so if one of these vitamins is present as a deficit, then neither vitamin works optimally in the body.

“Vitamin K has been called the next vitamin D, which has been one of the most widely run assays on LC-MS/MS equipment in the clinical diagnostics market. As the analysis of Vitamin K continues to evolve, IsoSciences will continue to expand into Vitamin K epoxides and additional MK derivative products,” stated Scott Landvatter, President of IsoSciences.

Vitamin K can exist naturally as vitamin K1 or vitamin K2 (commonly referred to MK or Menaquinone). Vitamin K1 is found in green leafy vegetables and vitamin K2 in cheese and natto (fermented soybeans). Vitamin K has been found to play a role in coagulation, tissue calcification and regulation of cellular functions. Vitamin K deficiency has been linked to adults taking vitamin K antagonists and infants who are exclusively breast fed. Adults taking sufficient vitamin K1 (daily intake of 120µg for males and 90µg for females) had a lowered risk of cardiovascular disease.

If you would have questions in reference to this new product offering, please contact Rich Tyburski, IsoSciences Vice President of Business Development by phone at (267) 983-6547 or email This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

About IsoSciences

IsoSciences, a MPD Chemicals company, is a leading supplier of stable isotope labeled vitamins, steroids, drug substances, metabolites and custom synthesis solutions. IsoSciences was founded in 2002, to fulfill the market needs for stable label isotopes of advanced intermediates and final drug substances. In addition, IsoSciences provides advanced new products that address the industry demands of the expanding LC-MS/MS market and the growing needs for isotopically labeled internal standards. IsoSciences has developed numerous novel catalog offerings for the clinical diagnostics and pharmaceutical markets.

Further, IsoSciences specializes in offering custom synthesis solutions for complex organic chemistry challenges, often involving isotopically labeled steps. IsoSciences is ISO9001 certified with extensive quality control and analytical capabilities. Additional capabilities include exact concentration solutions, along with a diverse catalog of compounds used in food, vitamin, steroid, hormone and diagnostic testing.

For more information please visit IsoSciences.com.


MPD Chemicals Exhibiting at the Specialty & Agro Chemicals America Conference September 8-10, 2014

MPD Chemicals Exhibiting at the Specialty & Agro Chemicals America, National Conference September 8-10, 2014

Visit Monomer Polymer and Dajac Labs, Silar and IsoSciences at Booth #11

MPD Chemicals will be exhibiting at the 3rd Annual Specialty & Agro Chemicals America Conference and Exhibit at booth #11, September 8-10, 2014, in Charleston, South Carolina, at the Charleston Marriott.



MPD Chemicals Announces Carrington Smith as new CEO

Trevose, PA – February 12, 2014

MPD Holdings, LLC, d/b/a MPD Chemicals (“MPD”), is pleased to announce the appointment of Carrington D. Smith, Ph.D. as Chief Executive Officer, effective February 1, 2014.  Dr. Smith is also elected a member of the Board of Managers.



Vitamin B12

Vitamin B12 (CAS 68-19-9), also known as cobalamin, is a vitamin that helps keep many areas of the body working properly. Areas like the brain and nervous system, are dependent on this nutrient, that helps produce blood and regulate DNA. Deficiencies in Vitamin B12, can lead to improper functions that can increase to more serious problems affecting the brain, and nerve damage.

Vitamin B12, is used to help those experiencing abnormalities in the mental and physical state of the body, and in some cases, cyanide poisoning. Symptoms of Vitamin B12 deficiency can include fatigue, loss of appetite, confusion, depression, numbness, and tingling in hands and feet. Megaloblastic anemia, a reduction of oxygen carried to the body's tissues because of larger and fewer immature red blood cells, can be caused by a lack of Vitamin B12.

The vitamin can be used to find and prevent another form of anemia, pernicious anemia. When vitamin B12 is detached from proteins in the food we eat, by the acid in the stomach, the nutrient then can be absorbed after fusing with the intrinsic factor, a stomach-made protein. Those who are unable to create intrinsic factor, have problems absorbing the vitamin. Testing vitamin levels is the first step to the prevention of disorders associated with deficiency.

Having high vitamin B12, can be just as detrimental as being deficient. Those who take in high quantities of foods that are rich in the nutrient such as meat, fish, dairy, and eggs, can have high levels. Others who have taken on a vegetarian, or vegan diet, tend to have low levels of the vitamin. One should be tested in these situations, or if enduring any of the various symptoms. Vitamin B12 shots may be administered, and there are nutrient supplements that can be taken to balance the levels, and ultimately better the state of the body.

As such IsoSciences offers an unlabeled form and is currently developing isotope labeled vitamin B12. If you wish to discuss purchase of this molecule, please contact us by email or phone (610-337-3762) we will be more than happy to provide assistance.

Vitamin B12


Vitamin B12 Testing

Doctors and clinical researchers typically perform Vitamin B12  (CAS 68-19-9) tests if a subject exhibits symptoms of dementia, confusion, weakness, loss of appetite, tingling in the extremities, rapid heart rate or a reduction in red blood cells due to malabsorption in the intestines called pernicious anemia.

How Does Vitamin B12 Testing Work?

Vitamin B12 testing is performed through venipuncture, typically entering at the back of the hand or inner elbow veins. Lancets are often used on infants or small children, collecting the specimen in a test strip or on a slide rather than a blood vial. Most commonly and accurately, analyzing the specimen for picograms per milliliter (pg/mL) will determine the subject's lack of B12 or normalcy.  Though other measurements do exist, they increase the occurrence of false-normal readings (see "weaknesses" below).

Normal values for B12 in the blood will fall into the 200 - 900 pg/mL range and may differentiate or fluctuate based on variables within the lab. If a subject's level falls below the 200 pg/mL range, they are said to show signs of a vitamin B12 deficiency. At this level, it is likely the subject will already exhibit symptoms. 

Causes for Vitamin B12 Deficiency

The causes for Vitamin B12 deficiency can be determined by a Shilling Test and include (but are not limited to):

      Lack of B12 in diet

      Malabsorption diseases and conditions (e.g. celiac and Crohn's disease)



It is uncommon for B12 levels to be in excess of 900 pg/mL as urination typically clears the body of excess waste.  Still, excessive B12 levels might indicate a number of dangerous conditions including hepatitis or cirrhosis of the liver.

What are the Weaknesses of Vitamin B12 Testing?

The patient-side weaknesses of vitamin B12 testing include the typical risks of phlebitis and hematoma which arise during any venipuncture, but the greater concern arises during the analysis.  A rupture of any red blood cells (hemolysis) during the collection of the sample can have an impact on the results of the test.

False-normal results can also occur from poor measurement methods, though they have decreased in occurrence with the increase in popularity of measuring the pg/mL range.  This is because the pg/mL range only measures biologically active B12.

Recently developed blood tests utilize a mass spectrometry based technique to determine the overall aldosterone level. As such IsoSciences offers an unlabeled form and is currently developing a labeled form of Vitamin B12. If you wish to discuss purchase of this molecule, please contact us by email or phone (610-337-3762) we will be more than happy to provide assistance.

Vitamin B12 Testing


Vitamin E


Vitamin E (CAS 59-02-9) is the common name given to a group of eight compounds that include four isomers of tocopherol and four isomers of tocotrienol. The compounds are fat soluble and are relevant in a number of biological processes including the reduction of oxidative stress during fatty acid oxidation, as well as functions in gene processing and cell signalling. The most active of the compounds in human is alpha-tocopherol, which is why it is subsequently the most intensely studied of the compounds.

Known Vitamin E Functions

Vitamin E has mainly been studied as a reducer of oxidative stress due to its reactivity with free radicals, as it binds to them and is subsequently reduced by a hydrogen donor and returns to the original form. As vitamin E is fat-soluble, it is primarily found in cell membranes and acts as the first line of defence against external oxidative stress.

Vitamin E, particularly alpha-tocopherol, has been shown to inhibit protein kinase C and stimulate protein phosphatase 2A, which suggests a role in smooth muscle growth. The compounds also have an effect on gene expression of CTGF, a gene coding for connective tissue growth factor, which is a factor responsible for the repair of wounds and regeneration of damaged tissue.

Vitamin E Deficiency in Humans

As vitamin E is important in the development of connective tissue, vitamin E deficiency has been associated with poor neural conduction, leading to neurological issues such as myopathy and spinocerubellar ataxia. Vitamin E deficiency can also lead to blood issues such as anaemia due to the damage to red blood cells as well as poor immune response

Vitamin E Supplementation and Overdose in Humans

To date, studies that have examined additional supplementation with vitamin E has no significant effect in the well-being and health of humans. Supplementation does not increase longevity, does not decrease the risk of stroke or heart disease and does not impact blood sugar levels. In fact, studies are emerging that suggest that supplementation with vitamin E may contribute to prostate cancer development in men and osteoporosis in women.

An overdose of vitamin E, exceeding 1500 IU per day, has been shown to lead to a decrease in the ability of blood to coagulate, which may aggravate existing problems in patients using warfarin or aspirin. An excess of vitamin E may also lead to a deficiency of vitamin K, the compound responsible for blood clotting.

The possible effects of over and underdosing of Vitamin E, medical practices utilize external analytical labs for Mass Spectrometry-focused testing in order to determine the right treatment protocol. These labs utilize stable isotope labeled Vitamin E in order to complete the analysis. IsoSciences offers unlabeled vitamin E and the isotope labeled vitamin E (d6) form.

Vitamin E

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